Bio: 2008-06-15

Bioinorganic Electrochemistry

Title: Bioinorganic Electrochemistry
Author(s): Ole Hammerich, Jens Ulstrup
Series: n/a
Publisher: Springer
ISBN: 1402064993
Publication: 2007
Pages: 314

Description: Interfacial electrochemistry of redox metalloproteins and DNA-based molecules is presently moving towards new levels of structural and functional resolution. This is the result of powerful interdisciplinary efforts. Underlying fundamentals of biological electron and proton transfer is increasingly well understood although with outstanding unresolved issues. Comprehensive bioelectrochemical studies have mapped the working environments for bioelectrochemical electron transfer, supported by the availability of mutant proteins and other powerful biotechnology. Introduction of surface spectroscopy, the scanning probe microscopies, and other solid state and surface physics methodology has finally offered exciting new fundamental and technological openings in interfacial bioelectrochemistry of both redox proteins and DNA-based molecules. Inorganic Bioelectrochemistry provides a thorough and didactic overview of state-of-the-art bioelectrochemistry with prospects for forthcoming development. The book is organized in eight chapters written by leading international experts and covers crucial relevant topics such as electron and proton transfer in metalloprotein systems, electrochemistry and electrocatalysis of redox enzymes, and electrochemistry of DNA-based molecules. A wide variety of readers will find this volume of great interest. These include final year undergraduate and postgraduate students, university lecturers in inorganic and physical chemistry as well as the biochemical and biological sciences, and research staff in medical and biotechnological companies, catalysis research, and other industries.

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System Modeling in Cellular Biology : From Concepts to Nuts and Bolts

System Modeling in Cellular Biology : From Concepts to Nuts and Bolts
Book Publisher: The MIT Press (03 April, 2006)
ISBN: 0262195488
Book author: Zoltan Szallasi, Jörg Stelling, Vipul Periwal

Book Description:
Research in systems biology requires the collaboration of researchers from diverse backgrounds, including biology, computer science, mathematics, statistics, physics, and biochemistry. These collaborations, necessary because of the enormous breadth of background needed for research in this field, can be hindered by differing understandings of the limitations and applicability of techniques and concerns from different disciplines. This comprehensive introduction and overview of system modeling in biology makes the relevant background material from all pertinent fields accessible to researchers with different backgrounds.

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Signal Transduction in Cancer (Cancer Treatment and Research)

Signal Transduction in Cancer (Cancer Treatment and Research)
Springer | 1402073402 | Edition - 2002-12-31 | PDF |336 pages| 6.4 MB | Rapidshare & Megaupload&Aliceinwire

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously.
This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents.
Series Editor comments:
"The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

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Nature Reviews Molecular Cell Biology "All issues" - 2000 to 2006

Nature Reviews Molecular Cell Biology "All issues" - 2000 to 2006

Language: English | PDF - SWF - MOV | approx 700 MB

Nature Reviews Molecular Cell Biology
from its 1st issue to 2006 december
6years, 75 issues including highlights, reviews, perspectives, errata, supplemental videos, figures
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Maths from Scratch for Biologists

Alan J. Cann, "Maths from Scratch for Biologists"
Publisher: Wiley | ISBN: 0471498351 | PDF | 240 pages | 10 MB

Numerical ability is an essential skill for everyone studying the biological sciences but many students are frightened by the 'perceived' difficulty of mathematics, and are nervous about applying mathematical skills in their chosen field of study. Having taught introductory maths and statistics for many years, Alan Cann understands these challenges and just how invaluable an accessible, confidence building textbook could be to the fearful student. Unable to find a book pitched at the right level, that concentrated on why numerical skills are useful to biologists, he wrote his own. The result is Maths form Scratch for Biologists , a highly instructive, informal text that explains step by step how and why you need to tackle maths within the biological sciences.
Features:
An accessible, jargon-busting approach to help readers master basic mathematical, statistical and data handling techniques in biology
Numerous end of chapter problems to reinforce key concepts and encourage students to test their newly acquired skills through practise
A handy, time-saving glossary
A supplementary website with numerous problems and self-test exercises

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Plant Genetic Engineering (Developments in Plant Genetics and Breeding)

A.D. Arencibia, "Plant Genetic Engineering (Developments in Plant Genetics and Breeding)"
Elsevier Science; 1st ed edition | ISBN: 0444504303 | 284 pages | PDF | 16,9 Mb

Plant biotechnology offers important opportunities for agriculture, horticulture, and the pharmaceutical and food industry by generating transgenic varieties with altered properties. This is likely to change farming practice and reduce the potential negative impact of plant production on the environment. This volume shows the worldwide advances and potential benefits of plant genetic engineering focusing on the third millennium.
The authors discuss the production of transgenic plants resistant to biotic and abiotic stress, the improvement of plant qualities, the use of transgenic plants as bioreactors, and the use of plant genomics for genetic improvement and gene cloning. Unique to this book is the integrative point of view taken between plant genetic engineering and socioeconomic and environmental issues. Considerations of regulatory processes to release genetically modified plants, as well as the public acceptance of the transgenic plants are also discussed.
This book will be welcomed by biotechnologists, researchers and students alike working in the biological sciences. It should also prove useful to everyone dedicated to the study of the socioeconomic and environmental impact of the new technologies, while providing recent scientific information on the progress and perspectives of the production of genetically modified plants.

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Human Growth Hormone: Research and Clinical Practice (Contemporary Endocrinology)

Human Growth Hormone: Research and Clinical Practice (Contemporary Endocrinology)
Humana Press| 0896035050 | Edition - 2000-02-15 | PDF | 384 pages | 4.22 MB | rapidshare

In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH in clinical studies. Timely and innovative, Human Growth Hormone: Research and Clinical Practice will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.
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Ecosystems of the Deep Ocean (Ecosystems of the World, Volume 28)

Ecosystems of the Deep Ocean (Ecosystems of the World, Volume 28)
Elsevier | 044482619X | Edition - 2003-03 | PDF | 580 pages | 8.58 MB | Rapidshare & Megaupload

This volume examines the deep sea ecosystem from a variety of perspectives. The initial chapters examine the deep-sea floor, the deep pelagic environment and the more specialised chemosynthetic environments of hydrothermal vents and cold seeps. These environments are examined from the perspective of the relationship of deep-sea animals to their physico-chemical environment.
Later chapters examine the biogeography of the main deep oceans (Atlantic, Pacific and Indian) with particular attention to the downward flux of surface-derived organic matter and how this drives the processes within the deep-sea ecosystem. The peripheral deep seas including the polar seas and the marginal deep seas (inter alia the Mediterranean, Red, Caribbean and Okhotsk seas) are explored in the same context. The final chapters examine the processes occurring in the deep sea and include an analysis of why the deep sea has high species diversity, how the fauna respond to organic input and how species have adapted reproductive activity in the deep sea. The volume concludes with an analysis of the anthropogenic impact on the deep sea.

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Molecular Modelling: Principles and Applications, second edition

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This text provides a detailed description of the techniques employed in molecular modelling and computational chemistry. The first part of the book covers the two major methods used to describe the interactions within a system (quantum mechanics and molecular mechanics). The second part then deals with techniques that use such energy models, including energy minimisation, molecular dynamics, Monte Carlo simulations and conformational analysis. The author also discusses the use of more advanced modelling techniques such as the calculation of free energies and the simulation of chemical reactions. In addition he considers methods such as database searching that can be used to design new molecules with specific properties. Many of the topics are treated in considerable depth but the author assumes that the reader has only a basic knowledge of the relevant physical and chemical principles.

Most of the theoretical sections are accompanied by simple calculations together with examples drawn from the literature. The book is well illustrated and a colour plate section highlights the impact of computer molecular graphics. The book will prove a valuable text for postgraduate students and professionals and many sections will be useful to final-year undergraduates taking courses in molecular modelling or computational chemistry.

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Medicinal Plants of the World, Volume 3: Chemical Constituents, Traditional and Modern Medicinal Uses

An extraordinary compendium of information on herbal medicine, Medicinal Plants of the World, Volume 3 comprehensively documents the medicinal value of 16 major plant species widely used around the world in medical formulations. The book's exhaustive summary of available scientific data for the plants provides detailed information on how each plant is used in different countries, describing both traditional therapeutic applications and what is known from its use in clinical trials. A comprehensive bibliography of over 3000 references cites the literature available from a wide range of disciplines. This book offers an unprecedented collection of vital scientific information for pharmacologists, herbal medicine practitioners, drug developers, medicinal chemists, phytochemists, toxicologists, and researchers who want to explore the use of plant materials for medicinal and related purposes.

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Plant Propagation by Tissue Culture: Volume 1. The Background

Plant Propagation by Tissue Culture: Volume 1. The Background
Springer | 1402050046 | Edition - 2007-11 | PDF | 520 pages | 2 MB | Rapidshare & Megaupload&Aliceinwire

Procedures for plant tissue culture have been developing from ca. 1930 onwards and are now essential in many domains of science and teaching. The use of these techniques for plant propagation only began to emerge some 40 years later. The first edition of “Plant Propagation by Tissue Culture” by Edwin F. George appeared in 1986. A second edition consisting of two volumes appeared in 1993 and 1996. For researchers and students, George’s books have become the standard works on in vitro plant propagation. These volumes also contain a wealth of information crucial for researchers and companies working in related areas; particularly plant breeding, genetic engineering, phytopathology, production of secondary metabolites and conservation. Scientific knowledge has expanded rapidly since the second edition and it would now be a daunting task for a single author to cover all aspects adequately. Therefore, in this third edition, topics are being covered by a number of specialists in the field. However, this edition still maintains the integration that was characteristic of the previous editions. The first volume of the new edition highlights the scientific background of in vitro propagation. The second volume, which is in preparation, will cover the practice of micropropagation and describe its various applications.

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Model Plants and Crop Improvement

Model Plants and Crop Improvement
CRC Press | ISBN: 0849330637 | 2006-09-29 | PDF | 344 pages | 3.12 Mb | RS
Within the past decade, there has been an explosion of research in both the public and private sectors regarding the use of plant genetic models to improve crop yield. Bringing together experts from across the globe, Model Plants and Crop Improvement provides a critical assessment of the potential of model plant species for crop improvement. The first comprehensive summary of the use of model plant systems, the book delineates the model species' contribution to understanding the genomes of crop species. The book provides an in-depth examination of the achievements and limitations of the model paradigm. It explores how continued research in models can contribute to the goal of delivering the outputs of molecular biology to crops. Covering the major genetic models such as Arabidopsis thaliana, Lotus japonicus, and Medigago, the book goes on to discuss applications to food plants of global importance including rice, canola, and legumes. The book introduces the evolutionary, genetic, genomic, and morphological attributes of B. distachyon that make it such an attractive new model plant system. As the post-genomic era dawns, a key question to address is how this growing body of genetic and biological information can be extended beyond the model to the modeled species. This book takes you one step closer to applying modeling results to crops in the field.

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Plant Proteomics: Methods and Protocols (Methods in Molecular Biology, Vol 355)

Plant Proteomics: Methods and Protocols (Methods in Molecular Biology, Vol 355)
Humana Press | 1588296350 | Edition - 2007-10-28 | PDF | 399 pages | 4.21MB | Rapidshare & Megaupload

Plant Proteomics: Methods and Protocols provides up-to-date methods and protocols for plant proteomics, each written by expert researchers from leading laboratories. Experimental methodologies are explained in clear and complete detail for both the wet and dry laboratories. The methods and protocols presented in this volume will inspire the novice as well as the expert researcher to undertake new experimental endeavors in plant proteomics.

Chapters 1 and 2 describe standard protocols and chapters 3 through 10 contain optimized protocols for protein extraction of tissues such as cereal seeds, xylem, phloem sap, of woody plants, and of cellular compartments, such as chloroplasts and mitochondria. These methods rely on improvements to solubilization of proteins, which is the emphasis of Chapters 11 and 12. Chapters 13 to 23 outline methods for protein identification, including 2DLC or LC of intact proteins, mass spectrometry (MALDI-TOF and MS/MS) with proteins separated by 2D gels, blue native ID gels, and Edman sequencing. Chapters 24 to 29 focus on the rapidly expanding area of analysis of post-translational modifications and protein-protein relationships. Attention is also given to data that proteomics produces, including management of that data, and to statistical tools used for effective analysis.

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Gene Biotechnology

Gene Biotechnology
CRC Press | ISBN: 0849312884 | 2004 | PDF | 523 pages | 9.34 Mb | RS

Many scientists find themselves working in the laboratory without sufficient background in current biotechnology methods. Others want to keep up with the revolution in biotechnology and the flood of new methodologies. This book provides a solution for both: a multidisciplinary approach to the methods essential to biotechnical development. Covering state-of-the-art technologies and a broad range of practical applications, the Second Edition of Gene Biotechnology presents information that researchers and students need to understand and apply today's biotechnology techniques. It discusses a wide variety of approaches, from very basic methods to the latest, most sophisticated technologies, including gene manipulation methods. The book contains clearly detailed, step-by-step protocols with helpful troubleshooting tips. It addresses the needs of researchers in academic and commercial environments, and serves as a guide for graduate students designing, implementing, and evaluating experimental projects. Written by a team of internationally recognized scientists, this edition offers several notable features typically lacking in other works on the subject. The book presents protocols, as well as clear and simple explanations of the key principles and concepts behind the methods. It includes useful troubleshooting guides to help solve experimental problems, presenting a single, logically organized source for all the most important new methodologies. This unique resource provides the tools for success in molecular and cellular biology research today.

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Biotransformation and Bioprocesses (BIOTECHNOLOGY AND BIOPROCESSING SERIES

Biotransformation and Bioprocesses (BIOTECHNOLOGY AND BIOPROCESSING SERIES
Marcel Dekker | 0824747755 | Edition - 2004-03-01 | PDF | 371 pages | 8.8 MB | Rapidshare & Megaupload

From the laboratory to full-scale commercial production, this reference provides a clear and in-depth analysis of bioreactor design and operation and encompasses critical aspects of the biocatalytic manufacturing process. It clarifies principles in reaction and biochemical engineering, synthetic and biotransformation chemistry, and biocell and enzyme kinetics for successful applications of biocatalysis and bioprocess technologies in the food, chiral drug, vitamin, pharmaceutical, and animal feed industries. Studying reactions from small to supramolecules, this reference provides an abundant display of end-of-chapter problems to sharpen understanding of key concepts presented in the text.

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Downstream Processing of Proteins: Methods and Protocols (Methods in Biotechnology Volume 9)

Downstream Processing of Proteins: Methods and Protocols (Methods in Biotechnology Volume 9)
Humana Press | 0896035646 | Edition - 2000-03-31 | PDF | 240 pages | 1.5 MB | rapidshare

Mohamed A. Desai and a team of experienced biotechnologists review both conventional and novel isolation techniques used in industrial applications for the downstream processing of protein molecules. These techniques include primary and secondary separations during the isolation of biomolecules, as well as unique laboratory-scale research methods from academia with a potential for scale-up. Also treated are various strands of the downstream biological process essential for a successful product license application, including both the validation of DSP stages, and the design and validation of viral clearance stages during the purification process. Downstream Processing of Proteins: Methods and Protocols provides scientists everywhere, but particularly in the biopharmaceutical and biotechnology industry, with a much-needed introduction to this critical technology

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Immobilization Of Enzymes And Cells (Methods in Biotechnology)

Immobilization Of Enzymes And Cells (Methods in Biotechnology)
Humana Press | 449 pages | 2006-04-13 | ISBN: 1588292908 | PDF | 3.51MB
The second edition of Immobilization of Enzymes and Cells serves as an update as well as a compliment to the first edition. This volume now includes simple protocols for the immobilization of enzymes and cells that could be useful for application at industrial scale, novel protocols for immobilization in the future, and new chemical reactors able to overcome the limitations of a number of immobilized derivatives.

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Food Biotechnology, Second Edition

Food Biotechnology, Second Edition
CRC Press | ISBN: 0824753291 | 2005-10-11 | PDF | 2008 pages | 29.2 Mb | RS

Revised and updated to reflect the latest research and advances available, Food Biotechnology, Second Edition demonstrates the effect that biotechnology has on food production and processing. It is an authoritative and exhaustive compilation that discusses the bioconversion of raw food materials to processed products, the improvement of food quality, the importance of food safety, the design of ingredients for functional foods, and the biochemical advances made in traditional fermentation. It also provides an international perspective on the discipline as a whole. The content of the book is divided into three sections for easy reference. The first section provides an overview of the basic principles and explains microbial applications. The next section explains plant tissue culture techniques, genetic engineering of plants and animals, functional food ingredients and their health benefits, probiotics, antibody production for oral vaccines, and topics on enzyme technologies. The final section discusses food safety issues and the various bio-processing and fermentation biotechnologies used throughout the world. Food Biotechnology, Second Edition is an indispensable guide for anyone who needs to understand the latest information on food production and processing from a biotechnology perspective.

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Biotechnology: Changing Life Through Science vol 1-2-3

Biotechnology: Changing Life Through Science vol 1-2-3
UXL | ISBN:1414401515 | Edition - 2007-05-11 | PDF | pages | 866 | 37MB

Far from being a new branch of scientific discovery, biotechnology has been practiced for thousands of years; it affects everyday life in continuously evolving ways. Biotechnology: Changing Life Through Science aims to explore this complex subject in a way that is understandable for students with an emphasis on real-world applications of biotechnology.

It will explore the relationship between science (the natural world) and technology (the human-made world) and highlight its impact. Entries are separated into three volumes, each with a focus on a specific area of biotechnology impact:

* Volume 1: Medicine (covers health applications)
* Volume 2: Agriculture (covers food, nature and the environment)
* Volume 3: Industry (covers industrial uses)

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National Research Council, «Putting Biotechnology to Work: Bioprocess Engineering»

National Research Council, «Putting Biotechnology to Work: Bioprocess Engineering»
ISBN: 0309047854 | Publisher: National Academies Press | Publication Date: 1992-11 | Number Of Pages: 132 | pdf | 1,6 mb

Biotechnology is broadly defined in a 1991 Office of Technology Assessment report as "any technique that uses living organisms (or parts of organisms) to make or modify products, to improve plants or animals, or to develop microorganisms for specific uses." This technology has been instrumental in the development and implementation of processes for the manufacture of antibiotics and other pharmaceuticals, industrial sugars, alcohols,amino acids and other organic acids, foods, and specialty products through the application of microbiology, fermentation, enzymes, and separation technology.Engineers, working with life scientists, often achieved scale-up to industrial production in remarkably short periods. A relatively small number helped to catalyze, over a period of 50 years, the growth of the pharmaceutical, food, agricultural-processing, and specialty-product sectors of the U.S. economy to the
point where sales now exceed $100 billion/year.

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Clinical Applications of PCR 2nd ed (Methods in Molecular Biology, Vol 336)

In this updated second edition, leading researchers apply molecular diagnostics to the many recent advances that have occurred in polymerase chain reaction( PCR)-based technologies. Highlights include real-time PCR, which allows the technique to be performed in a quantitative manner with improved sensitivity, robustness, and resilience to carryover contamination, mass spectrometric analysis of nucleic acids, and circulating cell-free nucleic acids in plasma. The authors apply these innovations to a broad spectrum of applications, including gene expression, methylation, trace molecule, gene dosage, and single cell analysis.

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Good Laboratory Practice Regulations, Fourth Edition (Drugs and the Pharmaceutical Sciences)

Recent changes in the interpretation and enforcement of 21 CFR Part 11 have shifted the focus of Good Laboratory Practice (GLP) regulations to concentrate on the acceptance of electronic signatures, the archiving of data, the security of electronic documents, and the automation of laboratory procedures. This all-encompassing Fourth Edition addresses every critical aspect of Good Laboratory Practice (GLP) regulations and demonstrates effective strategies for implementation in a variety of laboratory settings. This updated and expanded classic text contains new information about applying 21 CFR Part 11 to the laboratory environment, GLP documentation systems, laboratory risk analysis, system validation and inspection, process analytical technologies, and cost control for the prevention of pitfalls and the assurance of compliance in numerous research environments.

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Mass Spectrometry of Protein Interactions (Wiley - Interscience Series on Mass Spectrometry)

Mass Spectrometry of Protein Interactions (Wiley - Interscience Series on Mass Spectrometry)
Wiley-Interscience | 0471793736 | Edition - 2007-08-10 | PDF | 137 pages | 2.12 MB | Rapidshare & Megaupload&Aliceinwire

The authoritative guide to analyzing protein interactions by mass spectrometry
Mass spectrometry (MS) is playing an increasingly important role in the study of protein interactions. Mass Spectrometry of Protein Interactionspresents timely and definitive discussions of the diverse range of approaches for studying protein interactions by mass spectrometry with an extensive set of references to the primary literature. Each chapter is written by authors or teams of authors who are international authorities in their fields. This leading reference text:
Discusses the direct detection of protein interactions through electrospray ionization (ESI-MS); ion mobility analysis; and matrix-assisted laser desorption/ionization (MALDI-MS) Covers the indirect analysis of protein interactions through hydrogen-deuterium exchange (HX-MS); limited proteolysis; cross-linking; and radial probe (RP-MS)
Guides researchers in the use of mass spectrometry in structural biology, biochemistry, and protein science to map and define the huge number and diversity of protein interactions Reviews the latest discoveries and applications and addresses new and ongoing challenges This is a comprehensive reference for researchers in academia and industry engaged in studies of protein interactions and an excellent text for graduate and postgraduate students.

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Flow Cytometry for Biotechnology

Description: Flow cytometry is a sensitive and quantitative platform for the measurement of particle fluorescence. In flow cytometry, the particles in a sample flow in single file through a focused laser beam at rates of hundreds to thousands of particles per second. During the time each particle is in the laser beam, on the order of ten microseconds, one or more fluorescent dyes associated with that particle are excited. The fluorescence emitted from each particle is collected through a microscope objective, spectrally filtered, and detected with photomultiplier tubes. Flow cytometry is uniquely capable of the precise and quantitative molecular analysis of genomic sequence information, interactions between purified biomolecules and cellular function. Combined with automated sample handling for increased sample throughput, these features make flow cytometry a versatile platform with applications at many stages of drug discovery. Traditionally, the particles studied are cells, especially blood cells; flow cytometry is used extensively in immunology. This volume shows how flow cytometry is integrated into modern biotechnology, dealing with issues of throughput, content, sensitivity, and high throughput informatics with applications in genomics, proteomics and protein-protein interactions, drug discovery, vaccine development, plant and reproductive biology, pharmacology and toxicology, cell-cell interactions and protein engineering.

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Methods in Plant Electron Microscopy and Cytochemistry

Methods in Plant Electron Microscopy and Cytochemistry
Humana Press| 0896038092 | Edition - 2000-06-29 | PDF | 312 pages| 8.8 MB | Rapidshare &Megaupload

Hands-on experimentalists describe the cutting-edge microscopical methods needed for the effective study of plant cell biology today. These powerful techniques, all described in great detail to ensure successful experimental results, range from light microscope cytochemistry, autoradiography, and immunocytochemistry, to recent developments in fluorescence, confocal, and dark-field microscopies. Important advances in both conventional and scanning electron microscopies are also fully developed, together with such state-of-the-art ancillary techniques as high-resolution autoradiography, immunoelectron microscopy, X-ray microanalysis, and electron systems imaging. Easy-to-use and up-to-date, Methods in Plant Electron Microscopy and Cytochemistry offers today's plant scientists a first class collection of readily reproducible light and electron microscopical methods that will prove the new standard for all working in the field.

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Morphology Methods: Cell and Molecular Biology Techniques

Morphology Methods: Cell and Molecular Biology Techniques
Humana Press| 0896039552 | Edition - 2001-06-15 | PDF | 422 pages| 2.4 MB | Rapidshare &Megaupload

Ricardo Lloyd, md, phd, provides critical and tutorial surveys of the cutting-edge molecular and cell biologic techniques used today in the analysis of cells and tissues in situ. These molecular-based histologic and morphologic techniques are described in step-by-step detail by hands-on experts, often those who have originated or perfected them. Among the techniques presented are laser capture microdissection, in situ hybridization, FISH, confocal laser scanning microscopy, in situ PCR, and tyramide amplification. Applications include the detection of infectious agents and DNA, the diagnosis of undifferentiated tumors and endocrine lesions, the metaphase analysis of whole blood cultures, and clonality analysis. In its integrated, state-of-the-art approach, Morphology Methods: Cell and Molecular Biology Techniques thoroughly details and applies the rich panoply of significant new cell and molecular biologic technologies to all the major problems confronting morphologic studies and diagnostic pathology today.

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Food Microbiology Protocols (Methods in Biotechnology)

John F. T. Spencer, Alicia L. Ragout de Spencer, "Food Microbiology Protocols (Methods in Biotechnology)"
Humana Press; 1st edition | ISBN: 089603867X | 512 pages | PDF | 3,4 Mb
Expert laboratorians present a wide ranging set of detailed techniques for investigating the nature, products, and extent of the microorganisms involved in the manufacture and spoilage of foodstuff. The methods cover pathogenic organisms that cause spoilage, microorganisms in fermented foods, and microorganisms producing metabolites that affect the flavor or nutritive value of foods. Included in the section dealing with fermented foods are procedures for the maintenance of lactic acid bacteria, the isolation of plasmid and genomic DNA from species Lactobacillus, and the determination of proteolytic activity of lactic acid bacteria. A substantial number of chapters are devoted to yeasts, their use in food and beverage production, and techniques for improving industrially important strains. Comprehensive and timely, Food Microbiology Protocols is a gold-standard collection of readily reproducible techniques essential for the study of the wide variety of microorganisms involved in food production, quality, storage, and preservation today.

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Flow Cytometry with Plant Cells: Analysis of Genes, Chromosomes and Genomes

Jaroslav Dolezel, Johann Greilhuber, Jan Suda, "Flow Cytometry with Plant Cells: Analysis of Genes, Chromosomes and Genomes"
Wiley-VCH; 1 edition (May 8, 2007) | ISBN: 3527314873 | 479 pages | PDF | 4,3 Mb

Targeted at beginners as well as experienced users, this handy reference explains the benefits and uses of flow cytometery in the study of plants and their genomes. Following a brief introduction that highlights general considerations when analyzing plant cells by flow cytometric methods, the book goes on to discuss examples of application in plant genetics, genomic analysis, cell cycle analysis, marine organism analysis and breeding studies.
With its list of general reading and a glossary of terms, this first reference on FCM in plants fills a real gap by providing first-hand practical hints for the growing community of plant geneticists.

Human Stem Cell Manual: A Laboratory Guide

Human Stem Cell Manual: A Laboratory Guide
Academic Press | 0123704650 | Edition - 2007-06-11 | PDF | 488 pages | 18.3 MB

Stem cells are self-replicating and undifferentiated, meaning their function is not yet cell, tissue, or organ-specific. Due to the unique nature of these cells, research into their biology and function holds great promise for therapeutic applications through replacement or repair of diseased and damaged cells. This reader-friendly manual provides a practical "hands on" guide to the culture of human embryonic and somatic stem cells. By presenting methods for embryonic and adult lines side-by-side, the authors lay out an elegant and unique path to understanding the science of stem cell practice. The authors begin with a broad-based introduction to the field, and also review legal and regulatory issues and patents. Each experimental strategy is presented with an historical introduction, detailed method, discussion of alternative methods, and common pitfalls. This lab guide for researchers also serves as a textbook for undergraduate and graduate students in laboratory courses.

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PRINS and In Situ PCR Protocols (Methods in Molecular Biology: Volume 334)

PRINS and In Situ PCR Protocols (Methods in Molecular Biology: Volume 334)
Humana Press | 1588295494 | Edition - 2006-04-01 | PDF | 264 pages | 2.2 MB | rapidshare

This completely revised and updated edition takes advantage of the many new developments and applications that have occurred in PRINS and in situ PCR technology, including a new fast multicolor PRINS method for identifying human chromosomes, PRINS protocols for in situ detection of unique sequences and point mutation analysis, a new dideoxy PRINS procedure, and in situ PCR and PRINS protocols for plants. The authors describe in detail various applications of PRINS in human (detection of gene deletions in cancer detection of fetal cells in maternal blood, and assessment of aneuploidy in brain tissues and embryos) as well as plant cells. Readily reproducible in situ PCR techniques are also presented for the detection of cytomegalovirus, and for use in combination with microdissection. In situ RT-PCR techniques are also given for use in plant or cancer investigation.

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Leading chemists and engineers concisely explain the principles behind microchip capillary electrophoresis and demonstrate its use in a variety of biochemical applications, ranging from the analysis of DNA, proteins, and peptides to single cell analysis and measuring the impact of surface modification on flow in microfluidic channels. Since surface chemistry must be carefully considered for optimal operation at this scale, the authors also discuss methods of both adsorbed and covalent surface modification for its control. Fabrication methods for producing microchips with glass, poly(dimethylsiloxane), and other polymers are also provided so that even novices can produce simple devices for standard separations. Microchip Capillary Electrophoresis: Methods and Protocols provides a practical starting point for either initiating research in the field of microchip capillary electrophoresis or understanding the full range of what can be done with existing systems.

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Membrane Protein Purification and Crystallization: A Practical Guide Second Edition

Membrane Protein Purification and Crystallization: A Practical Guide Second Edition
Academic Press | 0123617766 | Edition - 2002-12-04 | PDF | 316 pages | 15.7 MB | rapidshare

In Building Genetic Medicine, Shobita Parthasarathy shows how, even in an era of globalization, national context is playing an important role in the development and use of genetic technologies. Focusing on the development and deployment of genetic testing for breast and ovarian cancer (known as BRCA testing) in the United States and Britain, Parthasarathy develops a comparative analysis framework in order to investigate how national "toolkits" shape both regulations and the architectures of technologies and uses this framework to assess the implications of new genetic technologies.

BRCA testing was one of the most highly anticipated and publicized technologies of contemporary medicine. Parthasarathy argues that differences in the American and British approaches to health care and commercialization of research led to the establishment of different BRCA services in the two countries. In Britain, the technology was available through the National Health Service as an integrated program of counseling and laboratory analysis, and was viewed as a potentially cost-effective form of preventive care. In the United States, although BRCA testing was initially offered by a number of providers, one company eventually became the sole provider of a test available to consumers on demand..

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T. Gregory Dewey, "Fractals in Molecular Biophysics"

Historically, science has sought to reduce complex problems to their simplest components, but more recently it has recognized the merit of studying complex phenomena in situ. Fractal geometry is one such appealing approach, and this book discusses its application to complex problems in molecular biophysics. The book provides a detailed, unified treatment of fractal aspects of protein and structure dynamics, fractal reaction kinetics in biochemical systems, sequence correlations in DNA and proteins, and descriptors of chaos in enzymatic systems. In an area that has been slow to acknowledge the use of fractals, this is an important addition to the literature, offering a glimpse of the wealth of possible applications to complex problems.

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NMR Spectroscopy Explained: Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology

NMR Spectroscopy Explained : Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology provides a fresh, practical guide to NMR for both students and practitioners, in a clearly written and non-mathematical format. It gives the reader an intermediate level theoretical basis for understanding laboratory applications, developing concepts gradually within the context of examples and useful experiments.

* Introduces students to modern NMR as applied to analysis of organic compounds.
* Presents material in a clear, conversational style that is appealing to students.
* Contains comprehensive coverage of how NMR experiments actually work.
* Combines basic ideas with practical implementation of the spectrometer.
* Provides an intermediate level theoretical basis for understanding laboratory experiments.
* Develops concepts gradually within the context of examples and useful experiments.
* Introduces the product operator formalism after introducing the simpler (but limited) vector model.

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Yawen, Ed. Bai, "Protein Folding Protocols "

Yawen, Ed. Bai, "Protein Folding Protocols "
Humana Press; 1 edition (2007) | ISBN: 1588296229 | 327 pages | PDF | 3,6 Mb

Protein Folding Protocols presents protocols for studying and characterizing protein folding from the unfolded to the folded state. Covering experiment and theory, bioinformatics approaches, and state-of-the-art simulation protocols for better sampling of the conformational space, this volume describes a broad range of techniques to study, predict, and analyze the protein folding process.
Protein Folding Protocols also provides sample approaches toward the prediction of protein structure starting from the amino acid sequence, in the absence of overall homologous sequences. These approaches have tremendous implications, ranging from drug design, functional assignment, comprehension of the nature of regulation, understanding molecular machines, viral entry into cells, and putting together cellular pathways and their dynamics.
The protocols follow the successful Methods in Molecular Biologyâ„¢ series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

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Macromolecular Cyrstallography Protocols Vol.2: Structure Determination (Methods in Molecular Biology, Vol 364)

Macromolecular Cyrstallography Protocols Vol.2: Structure Determination (Methods in Molecular Biology, Vol 364)
Humana Press | 1588299023 | Edition - 2007 | PDF | 283 pages | 3.71 MB | Rapidshare & Megaupload

In the decade since publication of the first edition of Crystallographic Methods and Protocols the field has seen several major developments that have both accelerated the pace of structure determination and made crystallography accessible to a broader range of investigators. Volume I, Preparation and Crystallization of Macromolecules is dedicated to the crystallization and ways to increase the odds of obtaining crystals in macromolecules, while Volume 2, Structure Determination, covers both computational methods for characterizing crystals and solving structures.

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Sylvie, Ed. Doublie, "Macromolecular Cyrstallography Protocols V.2: Structure Determination"

Sylvie, Ed. Doublie, "Macromolecular Cyrstallography Protocols V.2: Structure Determination"
Humana Press; 1 edition (2007) | ISBN: 1588299023 | 283 pages | PDF | 3,5 Mb

Membrane Protein Purification and Crystallization: A Practical Guide Second Edition

Membrane Protein Purification and Crystallization: A Practical Guide Second Edition
Academic Press | 0123617766 | Edition - 2002-12-04 | PDF | 316 pages | 15.7 MB | rapidshare

Transactions on Computational Systems Biology VIII

Transactions on Computational Systems Biology VIII

Publisher: Springer | Language: English | ISBN:3540766383 | 354 pages | Data: 2007 | PDF | 2 MbDescription: The LNCS journal Transactions on Computational Systems Biology is devoted to inter- and multidisciplinary research in the fields of computer science and life sciences and supports a paradigmatic shift in the techniques from computer and information science to cope with the new challenges arising from the systems oriented point of view of biological phenomena.

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Information Technology Solutions for Healthcare

Description: Many of the changes occurring within medicine are being catalyzed by the proliferation of professional and social activity with the internet and mobile technology. Understanding of the way in which healthcare is being transformed by IT is key in the improvement of medical standards and reduction of cost. This book presents the current and future trends in the transformation of healthcare services in the Information Society Era. The synergy between computer technology and medical services has opened fascinating new possibilities for benefit in areas such as continuing care, chronic disease treatment and old people home monitoring, bringing with it the promise of essential changes in existing models of care delivery and system performance. This book addresses the priorities within international informatics and presents a complete and thorough survey of the most promising e-health technologies. This is illustrated with the inclusion of case reports indentifying real applications of the techniques, with the focus on providing an integrated overview of e-health, and the medical, sociological and technical aspects. The authors primary objective has been to provide an in-depth study of internet-enhanced healthcare services, while mobile technology is also reviewed in the context of modern wireless technologies. The authors have provided a unique analysis of the evolution of healthcare services. The book is illustrated by numerous examples and comes together to provide a valuable set of tele-care solutions available to modern informatics practice.

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The Zebrafish: Genetics, Genomics and Informatics, Volume 77, Second Edition (Methods in Cell Biology)

The Zebrafish: Genetics, Genomics and Informatics, Volume 77, Second Edition (Methods in Cell Biology)
Academic Press | 0125641729 | Edition - 2004-11-10 | PDF | 630 pages | 9.2 MB | Rapidshare & Megaupload

This volume of Methods in Cell Biology, the second of two parts on the subject of zebrafish, provides a comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 1999. This second volume covers advances in forward and reverse genetic techniques, provides an update on the zebrafish genome and gene/mutant mapping technologies, examines the new systems for efficient transgenesis in the zebrafish, provides an in-depth view of informatics and the emerging field of comparative genomics, and considers the extensive infrastructure now available to the zebrafish community.

* Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls
* Illustrates many techiques in full-color
* Summarizes the Zebrafish Genome Project [/center]

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Sequence Data Mining

Description: Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.

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Genetic Programming Theory and Practice IV (Genetic and Evolutionary Computation)

Rick Riolo, Terence Soule , Bill Worzel, "Genetic Programming Theory and Practice IV (Genetic and Evolutionary Computation)"
Springer; 1 edition (March 2007) | ISBN:0387333754 | 338 pages | PDF | 17,7 Mb

Genetic Programming Theory and Practice IV was developed from the fourth workshop at the University of Michigan’s Center for the Study of Complex Systems to facilitate the exchange of ideas and information related to the rapidly advancing field of Genetic Programming (GP). Contributions from the foremost international researchers and practitioners in the GP arena examine the similarities and differences between theoretical and empirical results on real-world problems. The text explores the synergy between theory and practice, producing a comprehensive view of the state of the art in GP application.

This volume represents a watershed moment in the GP field in that GP has begun to move from hand-crafted software used primarily in academic research, to an engineering methodology applied to commercial applications. It is a unique and indispensable tool for academics, researchers and industry professionals involved in GP, evolutionary computation, machine learning and artificial intelligence.

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Classification and Learning Using Genetic Algorithms: Applications in Bioinformatics and Web Intelligence

Sanghamitra Bandyopadhyay, Sankar K. Pal , "Classification and Learning Using Genetic Algorithms: Applications in Bioinformatics and Web Intelligence "
Springer; 1 edition (May 2007) | ISBN: 3540496068 | 311 pages | PDF | 6 Mb

This book provides a unified framework that describes how genetic learning can be used to design pattern recognition and learning systems. The book is unique in the sense of describing how a search technique, the genetic algorithm, can be used for pattern classification mainly through approximating decision boundaries, and it demonstrates the effectiveness of the genetic classifiers vis-à-vis several widely used classifiers, including neural networks. It provides a balanced mixture of theories, algorithms and applications, and in particular results from the bioinformatics and Web intelligence domains.

This book will be useful to graduate students and researchers in computer science, electrical engineering, systems science, and information technology, both as a text and reference book. Researchers and practitioners in industry working in system design, control, pattern recognition, data mining, soft computing, bioinformatics and Web intelligence will also benefit.

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Computational Neuroanatomy: Principles and Methods

Computational Neuroanatomy: Principles and Methods
Humana Press| 158829000X | Edition - 2002-07 | PDF | 488 pages| 6.12 MB | Rapidshare &Megaupload

In Computational Neuroanatomy: Principles and Methods, the path-breaking investigators who founded the field review the principles and key techniques available to begin the creation of anatomically accurate and complete models of the brain. Combining the vast, data-rich field of anatomy with the computational power of novel hardware, software, and computer graphics, these pioneering investigators lead the reader from the subcellular details of dendritic branching and firing to system-level assemblies and models. A companion CD-ROM includes software used in computational neuroanatomy, sample data files animations of the results reported in the book, high-resolution color illustrations, and links to useful websites.

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Biomedical Information Technology (Biomedical Engineering)

Biomedical Information Technology (Biomedical Engineering)
Academic Press | 0123735831 |Edition - 2007-08-15 | PDF | 688 pages | 12.38 MB | rapidshare&Megaupload

Mastering InDesign for Print Design and Production shows how experienced professionals with deadlines and billable hours use InDesign efficiently and effectively. Through the case studies and interviews, readers will find inspired to look beyond the over-emphasized basic features and into the depths of InDesign's utility for real-world print design.

The enormous growth in the field of biotechnology necessitates the utilization of information technology for the management, flow and organization of data. The field continues to evolve with the development of new applications to fit the needs of the biomedicine. From molecular imaging to healthcare knowledge management, the storage, access and analysis of data contributes significantly to biomedical research and practice.

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Dannie Durand, "Comparative Genomics: RECOMB 2007 International Workshop"

This book constitutes the refereed proceedings of the 5th RECOMB Comparative Genomics Satellite Workshop, RECOMB-CG 2007, held in San Diego, CA, USA, in September 2007.

The 14 revised full papers presented were carefully reviewed and selected from 18 initial submissions. The papers address a broad variety of aspects and components of the field of comparative genomics, ranging from quantitative discoveries about genome structure to algorithms for comparative inference to theorems on the complexity of computational problems required for genome comparison.

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Foundations of Comparative Genomics

This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics.

* Presents an historic overview of genome biology and its achievements
* Includes topics not covered in other books such as minimal and ancestral genomes
* Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level
* Critically reviews horizontal gene transfer and other contentious issues
* Covers comparative virology as a somewhat overlooked foundation of modern genome science
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Essential Bioinformatics by Jin Xiong

Essential Bioinformatics byJin Xiong
ISBN: 0521840988
Title: Essential Bioinformatics
Author: Jin Xiong
Publisher: Cambridge University Press
Publication Date: 2006-03-13
Number Of Pages: 352
Average Amazon Rating: 4.5
Summary:
Essential Bioinformatics is a concise yet comprehensive textbook of bioinformatics, which provides a broad introduction to the entire field. Written specifically for a life science audience, the basics of bioinformatics are explained, followed by discussions of the state-of-the-art computational tools available to solve biological research problems. All key areas of bioinformatics are covered including biological databases, sequence alignment, genes and promoter prediction, molecular phylogenetics, structural bioinformatics, genomics and proteomics. The book emphasizes how computational methods work and compares the strengths and weaknesses of different methods. This balanced yet easily accessible text will be invaluable to students who do not have sophisticated computational backgrounds. Technical details of computational algorithms are explained with a minimum use of mathematical formulae; graphical illustrations are used in their place to aid understanding. The effective synthesis of existing literature as well as in-depth and up-to-date coverage of all key topics in bioinformatics make this an ideal textbook for all bioinformatics courses taken by life science students and for researchers wishing to develop their knowledge of bioinformatics to facilitate their own research.

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Computational Text Analysis: For Functional Genomics and Bioinformatics

Publisher: Oxford University Press, USA; 1 edition
Language: english
ISBN: 0198567405
Paperback: 312 pages- (1 Mb)
Format: PDF
Data: April 4, 2006

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Bioinformatics and Functional Genomics

Jonathan Pevsner

ISBN: 978-0-471-21004-7

Paperback

792 pages

November 2003

Review

"…provides non-trivial tools and biological motivations to learn Bioinformatics (Journal of Statistical Computation & Simulation, January 2005)
"...ideal both for biologists who want to master the application of Bioinformatics to real-world problems and for computer scientists who need to understand the biological questions that motivate algorithms." (Quarterly Review of Biology, March-May 2005)
"…this appears to be an excellent textbook for graduate students and upper level undergraduate students." (Annals of Biomedical Engineering, July 2004, 32, 7)
"…highly recommended for academic and medical libraries, and for researchers as an introduction and reference…" (E-Streams, Vol. 7, No. 4)
“...an intriguing work targeted toward biologists wanting to solve problems...provides a compendium of many biological insights and breakthroughs and will be a useful resource...highly recommended.” (Choice, Vol. 41, No. 7, March 2004)

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