Tumor Suppressor Genes in Human Cancer (Cancer Drug Discovery and Development)

Tumor Suppressor Genes in Human Cancer (Cancer Drug Discovery and Development)
Humana Press 0896038076 Edition - 2001-01-15 PDF 386 pages 4.81 MB Rapidshare &Megaupload

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
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Antiangiogenic Agents in Cancer Therapy (Cancer Drug Discovery and Development)

Antiangiogenic Agents in Cancer Therapy (Cancer Drug Discovery and Development)
Humana Press 0896036413 Edition - 1999-01-15 PDF 450 pages 9.45 MB

Beverly Teicher and a panel of distinguished investigators survey the state-of-the-art of antiangiogenesis research from the lab bench to clinical trials. Timely and authoritative, the contributors summarize our current understanding of tumor growth and its dependence on vascular development, as well as the present status of antiangiogenic agents in preclinical and clinical development. In addition, the book also examines what is known about the mechanisms by which these therapeutic agents interfere with tumor vasculature and grapples with the problem of establishing criteria by which to assess their clinical efficacy. Antiangiogenic Agents in Cancer Therapy offers a unique cutting-edge compendium of antiangiogenic research, taking stock of what has been accomplished , where the experimental therapeutics of antiangiogenic agents is going, and the continuing evolution of their role in cancer treatment and novel drug development.
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