Checkpoint Controls and Cancer: Volume 2: Activation and Regulation Protocols (Methods in Molecular Biology)

Checkpoint Controls and Cancer: Volume 2: Activation and Regulation Protocols (Methods in Molecular Biology)

* Publisher: Humana Press; 1 edition (June 24, 2004)
* Language: English
* ISBN-10: 1588295001
* ISBN-13: 978-1588295002
Book Description

Prestigious researchers from ten different countries present readily reproducible experimental protocols to study the molecular components of checkpoint controls and their regulation. Described in step-by-step detail, these cutting-edge techniques offer novel approaches, such as the use of genome databases and siRNA, to analyzing how cells of the human body can escape proper surveillance to grow into a tumor. Additional experimental methods are provided for the manipulation of checkpoint pathways and the analysis of the resulting consequences for the cellular phenotype. An earlier first volume, Reviews and Model Systems, comprehensively reviews the complexities of checkpoint controls and the model systems needed to study them.

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Marc S. Penn/ "Stem Cells And Myocardial Regeneration (Contemporary Cardiology) "

Marc S. Penn/ "Stem Cells And Myocardial Regeneration (Contemporary Cardiology) "
Humana Press; 1 edition (2007) | ISBN: 1588296644 | 315 pages | PDF | 2,7 Mb

Stem Cells and Myocardial Regeneration is a comprehensive bench to bedside examination of stem cell-based therapies for cardiac dysfunction. The contributors, all leading researchers in their area of expertise, explore recent advances in the laboratory and in clinical trials. This volume emphasizes the near epidemic status of chronic heart failure (CHF) in the United States and abroad, and evaluates the level of success and failure of current optimal medical therapy. Specific attention is also given to both the basic cell types and pathways involved in cardiac stem cell research and the clinical issues that surround it.

Parts I and II of Stem Cells and Myocardial Regeneration examine various cardiac stem cell types, including hematopoietic, mesenchymal, and endogenous cells and critical physiological pathways, including chemokines, stem cell differentiation, and arrhythmia mechanisms. Part III focuses on clinical issues intrinsic to delivery of stem cells to the heart at the time of myocardial infarction (MI) and in patients with CHF. Part IV contains up-to-date reviews and analyses of the findings of stem cell-based clinical trials of acute MI and CHF. The concluding section presents a summary of cardiac stem cell research and outlines potential obstacles to future study.
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Human Embryonic Stem Cell Protocols (Methods in Molecular Biology)

Human Embryonic Stem Cell Protocols (Methods in Molecular Biology)
Humana Press | ISBN 1588294978 | 2006-03-01 | PDF | 8.1 MB | 408 pages
A comprehensive collection of diverse techniques for the molecular and cellular manipulation of human embryonic stem (hES) cells. These readily reproducible methods have been optimized for the derivation, characterization, and differentiation of hES cells, with special attention given to regenerative medicine applications. A companion CD provides color versions of all illustrations in the book. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
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Stem Cell Biology (Cold Spring Harbor Monograph Series, 40)

Stem Cell Biology (Cold Spring Harbor Monograph Series, 40)
Springer | ISBN: 3540333355 | Edition - 2006-10-05 | PDF | 293 pages | 5.2 Mb

Human neurological and neuromuscular disorders caused by nucleotide expansion, first discovered in 1991, are the focus of growing interest of practicing physicians and of interested biomedical researchers. This volume represents a comprehensive and up-to-date description of many of the better-studied disorders. The expert authors discuss molecular, clinical and pathological aspects of the diseases as well as our current understanding of their underlying mechanisms. Of special interest are ideas and initial results of the different therapeutic strategies that can be employed to overcome some of the disorders. As a summary of the state-of-the-art research in this field, this book is of value to human geneticists, molecular biologists and biochemists as well as to practicing neurologists and pediatricians.
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