Recombinant Protease Inhibitors in Plants

Recombinant Protease Inhibitors in Plants
Publisher: Landes Bioscience | 2000-09-28 | ISBN 1587060078 | Pages: 241 | PDF | 2.3 Mb
Chapters available from this book

Appendix III. Tertiary Structures of Proteases and Protease Inhibitors Available in the Brookhaven and National Laboratory Protein Data Bank
Appendix II. Plant Protease Inhibitors: Availabe mRNA Sequences
Appendix I. Substrates and Inhibitors Useful in Protease Characterization
Protease Inhibitors in Food Processing more...

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Proteasomes : The World of Regulatory Proteolysis (Molecular Biology Intelligence Unit)

Proteasomes : The World of Regulatory Proteolysis (Molecular Biology Intelligence Unit)
Publisher:LANDES BIOSCIENCE PUBLISHERS | 2001-02-15 | ISBN 1587060116 | Pages:391 | PDF | 5.5 Mb

This book highlights proteasome structures and how they are related to different aspects of proteasome function. Moreover, the book reports on the functional roles these highly developed proteolytic machines play within the cell. It was a great surprise to the scientific world that proteolysis provides crucial functions in cellular regulation. The surprise was even greater when it was found that not lysosomes, but protease complexes with remarkably sophisticated architectures were responsible for the control of essential regulatory events. Excitingly, proteasomes were found to be involved in widespread functions of cell physiology, which included degradation of protein waste, antigen presentation, regulation of cell metabolism and cell differentiation as well as control of the cell cycle. The discovery of such multiple and essential functions made investigation of proteasome mediated regulatory proteolysis a highly significant theme in cell biology. Written by pioneers in the field the book represents a comprehensive up-to-date view on proteasome structures and functions from the ultimate frontier of cell biology research. It ties the reader to all facets of cell function. This work is an indispensable source for scientists working in the fields of basic and applied cell biology and immunology. Different aspects of proteasome functions are associated with the development of detrimental diseases like cancer, neurodegeneration, cystic fibrosis or immune disorders. Therefore, data reviewed in this book are important for physicians and pharmacologists active in research, and experts in the pharmaceutical industry.

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Food Lipids: Chemistry, Nutrition, and Biotechnology

Food Lipids: Chemistry, Nutrition, and Biotechnology
CRC Press | ISBN: 0824707494 | 2002-04-17 | PDF | 1040 pages | 5.54 Mb | RS

Highlighting the role of dietary fats in foods, human health, and disease, this book offers comprehensive presentations of lipids in food. Furnishing a solid background in lipid nomenclature and classification, it contains over 3600 bibliographic citations for more in-depth exploration of specific topics and over 530 illustrations, tables, and equations to help clarify study. With contributions of more than 40 internationally renowned experts, the book covers conjugated linoleic acids in health, and food applications of lipids. Topics include lipid oxidation in foods and tissues; the chemistry and mechanisms of lipid and antioxidant reactions; lipid biotechnology and genetic engineering; and more.

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Springer Handbook of Enzymes, vol.36 - Class 2 Transferases IX: EC 2.7.1.38 - 2.7.1.112

Springer Handbook of Enzymes, vol.36 - Class 2 Transferases IX: EC 2.7.1.38 - 2.7.1.112
Publisher: Springer | Language: English | ISBN:3540478078 | 624 pages | Data: 2007 | PDF | 21 Mb

Description: The objective of the “Springer Handbook of Enzymes” is to provide in concise form data on enzymes sufficiently well characterized. Data sheets are arranged in their EC-Number sequence. The volumes are arranged according to enzyme classes. Considerable progress has been made in enzymology since the publication of the first edition (published as “Enzyme Handbook”): many enzymes are newly classified or reclassified. In the 2nd edition each entry is correlated with references and one or more source organisms. New datafields are created: “application” and “engineering” (for the properties of enzymes where the sequence has been changed). Altogether the amount of data has doubled so that the 2nd edition will consist of 39 volumes plus synonym index. This collection is an indispensable source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences.

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Springer Handbook of Enzymes, vol.38 - Class 2 Transferases XI: EC 2.7.6 - 2.7.7

Springer Handbook of Enzymes, vol.38 - Class 2 Transferases XI: EC 2.7.6 - 2.7.7
Publisher: Springer | Language: English | ISBN:3540715258 | 569pages | Data: 2007 | PDF | 2 Mb

Description: The objective of the “Springer Handbook of Enzymes” is to provide in concise form data on enzymes sufficiently well characterized. Data sheets are arranged in their EC-Number sequence. The volumes are arranged according to enzyme classes. Considerable progress has been made in enzymology since the publication of the first edition (published as “Enzyme Handbook”): many enzymes are newly classified or reclassified. In the 2nd edition each entry is correlated with references and one or more source organisms. New datafields are created: “application” and “engineering” (for the properties of enzymes where the sequence has been changed). Altogether the amount of data has doubled so that the 2nd edition will consist of 39 volumes plus synonym index. This collection is an indispensable source of information for researchers in biochemistry, biotechnology, organic and analytical chemistry, and food sciences.

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Peroxiredoxin Systems: Structures and Functions

Peroxiredoxin Systems: Structures and Functions
Publisher: Springer | Language: English | ISBN:1402060505 | 410 pages | Data: 2007 | PDF | 5 Mb

Description: The peroxiredoxins represent an important emerging family of sulfhydryl-linked antioxidant proteins, apparently ubiquitously present in all known organisms. The antioxidant function of the peroxiredoxins complements that of other enzymic and non-enzymic systems within the cell. In addition, there is increasing evidence that the peroxiredoxins play a role in cell signalling, by controlling and/or sensing hydrogen peroxide and peroxynitrite levels. In this, the first book containing a broad survey on the peroxiredoxins, the editors succeeded to involve almost all groups that contributed significant insights into the emerging field. The diverse biological roles of the new protein family are discussed in the context of other antioxidant systems like those based on heme or selenium catalysis. Finally, related future perspectives, which range from antimicrobial therapy up to the understanding of human development and carcinogenesis, are highlighted. Specifically, the book will be of outstanding interest to researchers who want to understand how micro-organisms, plants and animals cope with oxidative stress and how such stress is recognized and linked to adaptive responses via redox regulation of cellular processes.

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Calcium Signalling and Disease: Molcular Pathology of Calcium

Calcium Signalling and Disease: Molcular Pathology of Calcium
Publisher: Kluwer Academic Publishers | Language: English | ISBN: 1402061900 | 608 pages | Data: 2007 | PDF | 4.1 Mb

Description: This topic is a new entry in the area of cellular calcium signaling: yet, it now spans the entire area, with discoveries that cover both genetic and acquired pathologies, even offering glimpses in the direction of therapy. Cellular calcium homeostasis, and thus calcium signalling, is mainly regulated by membrane intrinsic proteins and calcium sensor proteins. Both classes may be involved in pathological processes that affect both human and animals, ranging from common and important diseases (e.g. migraine, diabetes, epilepsia, manic depression, infertility, various types of cancer, Alzheimer’s disease, muscular dystrophy) to rare genetic conditions (e.g., a number of genetic heart conditions, autoimmune retinopathies, night blindness, hereditary amyloid polyneuropathy, malignant hyperthermia, cerebellar ataxia, atherothrombotic disease). Clearly, the topic has now become not only very large, but also very stimulating. Its extensive critical coverage is likely to eventually stimulate fruitful interdisciplinary discussions.

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Alkaliphiles: Genetic Properties and Applications of Enzymes

Alkaliphiles: Genetic Properties and Applications of Enzymes
Publisher: Springer | Language: English | ISBN:354033372X | 270 pages | Data: 2006 | PDF | 11 Mb

The pioneering work of Dr. Koki Horikoshi on the discovery, research and applications of alkaliphilic bacteria are described here in their entirety. The isolation, distribution and taxonomy of alkaliphilic microorganisms as well as their cell structure and physiology are discussed for a basic understanding of these entities. The molecular biology and genome sequencing of some alkaliphilic bacterial strains are also presented.

Part II of the volume focuses on enzymes of alkaliphiles and their applications. These include alkaline proteases, starch-degrading enzymes and numerous others. Some of these enzymes are currently in wide commercial use as laundry detergent additives and in wastewater treatment.

Alkaliphiles are a relatively recent field of research that will no doubt provide avenues to a wide range of further discoveries and applications for a new generation of workers in bioscience and technology.

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Enzymes in Nonaqueous Solvents: Methods and Protocols (Methods in Biotechnology Volume 15)

Enzymes in Nonaqueous Solvents: Methods and Protocols (Methods in Biotechnology Volume 15)
Humana Press | ISBN:0896039293 | Edition - 2001-01-15 | PDF | 704 pages | 3.21 MB | Rapidshare & Aliceinwire

In Enzymes in Nonaqueous Solvents: Methods and Protocols, leading chemists, biochemists, biotechnologists, and process engineers summarize for the first time a wide range of methods for executing enzymatic transformations under nonaqueous conditions. Each method includes detailed step-by-step instructions for its successful completion, a list of materials, and ancillary notes that explain the scientific basis of the procedure, as well as troubleshooting. Also provided are a generic description of key reactions, advice on biocatalyst preparation, discussion of reaction conditions, and instructions on bioreactor design.
Comprehensive and state-of-the-art, Enzymes in Nonaqueous Solvents: Methods and Protocols offers today's synthetic chemists, biochemists, and process engineers all the essential information needed to carry out enzymatic reactions in nonaqueous media, as well as to successfully scale up to production quantities.

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Proteolytic Enzymes: A Practical Approach

Proteolytic Enzymes: A Practical Approach
Oxford University Press, USA | 019963663X | Edition - 2001-03-15 | PDF |358 pages| 30.6 MB | rapidshare & Megaupload&Aliceinwire

Like the popular first edition, this new edition of Proteolytic Enzymes emphasizes practical aspects of the handling, characterization, inhibition, and use of proteolytic enzymes giving general advice and specific examples. The text and protocols have been thoroughly updated to take account of the advances made in the last 10 years in both the increased understanding of the role of peptidases in many critical cellular processes e.g. apoptosis and new technological developments e.g. in recombinant protein expression, protein sequencing, and structural studies. The topics covered are: nomenclature and classification; purification; assay methods; determination of mechanism; inhibition and prevention of unwanted proteolytic activity; characterizing natural inhibitors; proteolytic enzymes in peptide mapping and primary structure elucidation by mass spectrometry and Edman sequencing; limited proteolysis as a structural probe; synthetic function. This book will be as invaluable as the first edition in providing ideas and protocols for scientists either studying proteases or using proteases as a research tool.

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Frontiers in Research of the Renin-Angiotensin System on Human Disease

Frontiers in Research of the Renin-Angiotensin System on Human Disease
Publisher: Springer | Language: English | ISBN:1402063718 | 465 pages | Data: 2007 | PDF | 2.5 Mb

Description: The significant impact of the renin-angiotensin system (RAS) on basic research and its clinical relevance are reflected by the flourishing publication of original and review research articles; by the appearance of whole issues of journals dedicated to the RAS; and by specialist books on the RAS. In such a rapidly evolving environment, publications that span the spectrum from basic research to the bedside, fill a particularly valuable niche for clinicians and researchers alike. The primary aim of this book is to provide a topical and timely forum for the critical appraisal of an area of RAS research that is expanding rapidly. In this respect, a collection of thirteen chapters from distinguished and world-class experts in the field has been presented on the contemporary research of the RAS and their implications in human disease. It is clear that outstanding and stellar work on the novel roles of local RAS and their potential clinical application is being done in laboratories and clinics across the globe. This volume should be of general interest to the readership of our "Proteases in Biology and Disease" book series, as well as being a comprehensive book for basic scientists, clinicians and newcomers to this field.

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Creatine and Creatine Kinase in Health and Disease

Creatine and Creatine Kinase in Health and Disease
Publisher: Springer | Language: English | ISBN:1402064853 | 450 pages | Data: 2007 | Format: PDF | 2.8 Mb

Description: Although creatine was discovered already in the 1830s, it is only in recent years that its crucial role for human health and general well-being has been increasingly realized and appreciated. A number of beneficial health effects have been ascribed to oral creatine supplementation, such as neuroprotective, ergogenic, anti-diabetic, anti-inflammatory, antiviral, or antitumor effects. Creatine may even improve memory and intelligence. In the present book, emphasis is placed on the intricate interplay between creatine and creatine kinase function on one hand, and proper brain function, neurodegenerative disease and/or neuroprotection on the other hand.The book also elaborates on the recently identified inborn errors of creatine biosynthesis and transport, the so-called cerebral creatine deficiency syndromes. The clinical hallmarks of these disorders are mental retardation, epilepsy, autistic-like behaviour, and speech and language delay. In addition, the muscle growth- and strength-promoting effects, the pharmacokinetics and the safety of oral creatine supplementation are discussed. Finally, the present book outlines the emerging "systems biology" approaches for understanding the ...

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Handbook of Food Enzymology (Food Science and Technology)

Handbook of Food Enzymology (Food Science and Technology)
CRC Press | ISBN: 0824706862 | 2002-12-05 | PDF | 1128 pages | 19.9 Mb | RS

Discussing methods of enzyme purification, characterization, isolation, and identification, this book details the chemistry, behavior, and physicochemical properties of enzymes to control, enhance, or inhibit enzymatic activity for improved taste, texture shelf-life, nutritional value, and process tolerance of foods and food products. The book covers general aspects of enzymology and the biotechnological strategies for enzyme discovery and development. It describes prototypic enzymes of the six chemical types of reactions catalyzed by enzymes, addressing what the enzymes do, their importance to feed and food production, chemical and biological properties, activity measurement, and more.

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Protein Biochemistry and Proteomics (The Experimenter Series)

Protein Biochemistry and Proteomics (The Experimenter Series)
Academic Press | ISBN0:12088545X | Edition - 2006-02-21 | PDF | 256 pages | 3.5 MB | rapidshare&Megaupload

Hubert Rehm's Protein Biochemistry and Proteomics is more than a laboratory manual; it is a strategic guide that provides the reader with tips and tricks for more successful lab experiments. Using a conversational yet professional tone, Rehm provides an overview of a variety of methods in protein biochemistry/proteomics. He provides short and precise summaries of routine procedures as well as listings of the advantages and disadvantages of alternative methods. Readers will immediately sense that the author if very familiar with the challenges, and frustration of the daily lab routine. Never before has such an honest, tactical guide been available for those conducting lab experiments within the field of biochemistry.

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China International Symposium on Plant Glycosides (1997 Kunming , Chong-Ren Yang ), Osamu Tanaka, "Advances in Plant Glycosides, Chemistry and Biology

China International Symposium on Plant Glycosides (1997 Kunming , Chong-Ren Yang ), Osamu Tanaka, "Advances in Plant Glycosides, Chemistry and Biology"
Elsevier Science Pub Co | ISBN: 0444501800 | 458 pages | PDF | 17,8 Mb

In the plant kingdom a variety of chemical constituents occur in a glycoside form (conjugation with sugar). Glycosides are important, secondary metabolites. The structural diversity is a result of the vast amount of varieties and stereochemical configurations of the sugar component. Aglycones belong to terpenoid, steroid, flavonoid, quinonoid, lignan, other simple phenolics, and isothiocyanate. However, biological activities of glycosides are, in many cases, susceptible to the nature of sugar moieties, even though their aglycone is the same.

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A Manual for Biochemistry Protocols (Manuals in Biomedical Research)

Markus R. Wenk, Aaron Z. Fernandis, "A Manual for Biochemistry Protocols (Manuals in Biomedical Research)"
World Scientific Publishing Company; 1 Spi edition (March 30, 2007) | ISBN: 9812700668 | 140 pages | PDF | 1,5 Mb

Biochemistry plays an important role in all areas of the biological and medical sciences. With most of the research or diagnosis involved in these areas being based on biochemically obtained observations, it is essential to have a profile of well standardized protocols. This manual is a basic guide for all students, researchers and experts in biochemistry, designed to help readers in directly starting off their experiments without prior knowledge of the protocol. The book dwells on the concepts used in designing the methodologies, thereby giving ample room for researchers to modify them according to their research requirements.

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Carbonic Anhydrase: Its Inhibitors and Activators
CRC Press | ISBN: 0415306736 | 2005-05-27 | PDF | 376 pages | 8.59 Mb | RS

Carbonic anhydrases (CAs) are metalloenzymes that regulate important physiological functions in organisms throughout the plant and animal kingdoms. These enzymes are found in numerous forms, and in numerous tissues, and present an attractive target for the design of inhibitors and activators with therapeutic value. CA inhibitor-based drugs have been approved for the treatment of glaucoma, and show promise in the areas of oncology, gastroenterology, neurology, nephrology and dermatology; CA activators may prove useful in treating Alzheimer's disease and memory disorders. Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of internationally recognized experts, this authoritative edition is a leading reference for bioscientists across many disciplines, as well as novices interested in the latest developments in this complex field. An understanding of the mechanisms through which carbonic anhydrases interact with their inhibitors and activators in complex biological environments is essential in developing novel therapeutic agents for the treatment of disease.

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Cytokine Inhibitors

Cytokine Inhibitors
CRC Press | ISBN: 0824704347 | 2001-01-15 | PDF | 372 pages | 3.58 Mb | RS

Compiling an up-to-date and detailed survey of the role cytokines play in cell-to-cell communication, development, and differentiation, this comprehensive reference highlights the medical advantages of cytokine inhibition and pursues novel methods of discovery for more potent and specific blocking agents. Investigates the pathogenic role of cytokines and the potential of cytokine inhibitors as anti-inflammatory, anticancer, antiviral agents! Written by 25 recognized experts revealing recent breakthroughs in research, Cytokine Inhibitors · illustrates cases of naturally produced or in vitro engineered polypeptide cytokine blocking agents · describes all possible approaches to cytokine inhibitors, including monoclonal antibodies, soluble receptors, engineered mutant cytokines, and small-molecular-weight receptor antagonists and signaling inhibitors · clearly explains the homeostatic function of cytokine inhibition and verifies therapeutic approaches effecting natural responses in organisms · discusses the results of clinical trials and therapeutic applications of first-generation recombinant receptor antagonists, such as the potential of tumor necrosis factor antagonists as prominent tools in the therapy of chronic inflammatory conditions · concentrates on the clinical development of second-generation small-molecular-weight, orally bioavailable cytokine inhibitors · reviews the improved understanding of intracellular signaling pathways, the structural determinants responsible for cytokine-receptor interaction · lists the three-dimensional structure, relevant receptors, and intracellular tyrosine kinases of cytokines · and much more! Containing over 1400 references as well as tables and drawings, Cytokine Inhibitors serves as an exemplary reference for basic and clinical immunologists; allergists; biochemists; pathologists, hematologists; experimental, cell, and molecular biologists; rheumatologists; infectious disease specialists; medicinal chemists; and medical school and upper-level undergraduate and graduate students in these disciplines.

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Directory of Therapeutic Enzymes

Directory of Therapeutic Enzymes
CRC Press | ISBN: 0849327148 | 2005-08-12 | PDF | 312 pages | 9.75 Mb | RS

Carefully crafted to provide tightly focused and authoritative information, the Directory of Therapeutic Enzymes covers all approved therapeutic enzymes currently used in medicine. Written mainly by industry experts, the book includes information sourced directly from the company that developed or manufactured the product. It explores major development issues, from manufacturing and marketing to delivery of the finished product. Chapter 1 reviews applied enzymology while chapter 2 delineates theory and applications. Between them, the first two chapters set the appropriate backdrop for the remaining chapters, which focus on actual enzyme products that have gained regulatory approval for general medical use. The chapter authors discuss the biochemistry of the enzymes, the reactions they catalyze, how they are produced or manufactured, and their medical applications. The book highlights the many applications of approved therapeutic enzymes, including use in the treatment of blood-clotting disorders, certain cancers, and a variety of genetic disorders. Illustrated with tables and figures that support the text, the book is a single source of in-depth technical information.

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Hormone Assays in Biological Fluids

Hormone Assays in Biological Fluids

Humana Press | 2006-01-16 | ISBN:1588290050 | 272 pages | pdf | 1.73 Mb
Expert researchers who have developed and applied significant new assays describe in step-by-step detail a variety of methods for measuring a broad variety of hormones, related peptides, and synthetic steroids in various biological fluids. The hormones measured range from glucocorticoids in biological fluids, urinary steroids, aldosterone in blood, and plasma renin activity, to gut hormones in plasma, melatonin, prolactin, 6-sulfatoxymelatonin, and androgens in blood, saliva, and hair. The emphasis is on noncommercial assays so that investigators can set up novel methods suited to their special needs. Commercial assays are also described for comparative purposes. Tutorials on radioimmunoassay, gas chromatography-mass spectrometry, high-performance liquid chromatography, and PCR techniques help the reader to choose the best method for his or her purpose.

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