Guide to Analysis of DNA Microarray Data

Guide to Analysis of DNA Microarray Data
Publisher: John Wiley & Sons | Pages: 168 | 2004 | ISBN: 0471656046 | PDF | 6.9 MB

Written for biologists and medical researchers who don't have any special training in data analysis and statistics, Guide to Analysis of DNA Microarray Data, Second Edition begins where DNA array equipment leaves off: the image produced by the microarray. The text deals with the questions that arise starting at this point, providing an introduction to microarray technology, then moving on to image analysis, data analysis, cluster analysis, and beyond.
With all chapters rewritten, updated, and expanded to include the latest generation of technology and methods, Guide to Analysis of DNA Microarray Data, Second Edition offers practitioners reliable information using concrete examples and a clear, comprehensible style. This Second Edition features entirely new chapters on:

* Image analysis
* Experiment design
* Automated analysis, integrated analysis, and systems biology
* Interpretation of results
Intended for readers seeking practical applications, this text covers a broad spectrum of proven approaches in this rapidly growing technology. Additional features include further reading suggestions for each chapter, as well as a thorough review of available analysis software.
Rapidshare
Mirror

Tracking Genetically - Engineered Microorganisms (Biotechnology Intelligence Unit 2)

Tracking Genetically - Engineered Microorganisms (Biotechnology Intelligence Unit 2)
Publisher: LANDES BIOSCIENCE PUBLISHERS | 2000-06-15 | ISBN 1587060094 | Pages: 162 | PDF | 1.8 Mb

This book is an unparalleled, very comprehensive survey of methods for monitoring of specific microorganisms in the environment, with great usefulness for those working in either the assessment of risks of released GMMs or with monitoring of released microorganisms in e.g. soil bioremediation or biocontrol. The aim is to provide a background in different techniques for monitoring of specific microorganisms in environmental samples along with examples of applications of these approaches. The examples include work done in laboratory model systems (microcosms) as well as documentation from actual field releases of genetically modified microorganisms. The regulatory aspects of risk assessment of genetically modified microorganisms targeted for release are also included. Therefore, this book is unique in dealing with different aspects of monitoring of GMMs and should be useful for regulatory agencies that require a summary of existing techniques and information as well as scientists that require a review of the "state-of the art" of modern methods for monitoring specific microorganisms in nature.
Download
Rapidshare
Mirror

Gregor Mendel: And the Roots of Genetics (Oxford Portraits in Science)
Oxford University Press, USA | 0195122267 | Edition - 1999-03-31 | PDF | 112 pages| 7.26 MB | Rapidshare & Megaupload

When Gregor Mendel passed away in 1884, not a single scholar recognized his epochal contributions to biology. The unassuming abbot of the Augustinian monastery in Brno (in today's Czech Republic) was rediscovered at the turn of the century when scientists were stunned to learn that their findings about inheritance had already been made by an unknown monk three decades earlier. A dedicated researcher who spent every spare hour in the study of the natural sciences, Mendel devised a series of brilliantly simple experiments using a plant easily grown on the monastery's grounds--the garden pea. In the course of just a few years he made the famous discoveries that later became the centerpiece of the science of heredity. In an entertaining and thoroughly informed narrative, Edward Edelson traces Mendel's life from his humble origins to his posthumous fame, giving us both a brief introduction to the fascinating science of genetics and an inspired account of what a modest man can accomplish with dedication and ingenuity. Oxford Portraits in Science is an ongoing series of scientific biographies for young adults. Written by top scholars and writers, each biography examines the personality of its subject as well as the thought process leading to his or her discoveries. These illustrated biographies combine accessible technical information with compelling personal stories to portray the scientists whose work has shaped our understanding of the natural world.

Download

Rapidshare

Megaupload

An Introduction to Forensic Genetics

An Introduction to Forensic Genetics
Publisher: Wiley | Pages:162 | 2007-11-02 | ISBN:0470010266 | PDF| 2.2 MB

An Introduction to Forensic Genetics is a comprehensive introduction to this fast moving area from the collection of evidence at the scene of a crime to the presentation of that evidence in a legal context. The last few years have seen significant advances in the subject and the development and application of genetics has revolutionised forensic science.


This book begins with the key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field, illustrated throughout with references to relevant casework. In addition to the technology involved in generating a DNA profile, the underlying population biology and statistical interpretation are also covered. The evaluation and presentation of DNA evidence in court is discussed as well with guidance on the evaluation process and how court reports and statements should be presented.

* An accessible introduction to Forensic Genetics from the collection of evidence to the presentation of that evidence in a legal context
* Includes case studies to enhance student understanding
* Includes the latest developments in the field focusing on the technology used today and that which is likely to be used in the future
* Accessible treatment of population biology and statistics associated with forensic evidence

This book offers undergraduate students of Forensic Science an accessible approach to the subject that will have direct relevance to their courses. An Introduction to Forensic Genetics is also an invaluable resource for postgraduates and practising forensic scientists looking for a good introduction to the field.

Download

Rapidshare

Mirror

Translational Control of Gene Expression (Cold Spring Harbor Monograph Series)

Translational Control of Gene Expression (Cold Spring Harbor Monograph Series)
COLD SPRING HARBOR LABORATORY PRESS | 0879695684 | Edition - 2000| PDF |1020 pages| 6.5 MB | rapidshare & Megaupload

Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translational control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translational machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.
Download

Rapidshare

Megaupload

Aliceinwire

Translational Control of Gene Expression

Translational Control of Gene Expression
Publisher: CSPH Press | Language: English | ISBN: 0879695684 | 1020 pages | Data: 2007 | PDF | 11 Mb

Description: Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translational control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translational machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.

Download:
MegaUpload
Easy-share

Molecular Photofitting: Predicting Ancestry and Phenotype Using DNA

Molecular Photofitting: Predicting Ancestry and Phenotype Using DNA
Academic Press | 0120884925 | Edition - 2007-09-21 | PDF | 634 pages | 10 MB | Rapidshare & Megaupload&Aliceinwire
In the field of forensics, there is a critical need for genetic tests that can function in a predictive or inferential sense, before suspects have been identified, and/or for crimes for which DNA evidence exists but eye-witnesses do not. Molecular Photofitting fills this need by describing the process of generating a physical description of an individual from the analysis of his or her DNA. The molecular photofitting process has been used to assist with the identification of remains and to guide criminal investigations toward certain individuals within the sphere of prior suspects.

Molecular Photofitting provides an accessible roadmap for both the forensic scientist hoping to make use of the new tests becoming available, and for the human genetic researcher working to discover the panels of markers that comprise these tests. By implementing population structure as a practical forensics and clinical genomics tool, Molecular Photofitting serves to redefine the way science and history look at ancestry and genetics, and shows how these tools can be used to maximize the efficacy of our criminal justice system.

* Explains how physical descriptions of individuals can be generated using only their DNA
* Contains case studies that show how this new forensic technology is used in practical application
* Includes over 100 diagrams, tables, and photos to illustrate and outline complex concepts
Download

Rapidshare

Megaupload

Aliceinwire

The Genetics of Male Fertility

bkThe Genetics of Male Fertility
Humana Press | 1588298639 | Edition - 2004 | PDF | 337 pages| 2.08 MB | Rapidshare & Megaupload

Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments.
This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms.
Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.
Download

Rapidshare

Megaupload

Aliceinwire

Green Gene Technology: Research in an Area of Social Conflict (Advances in Biochemical Engineering / Biotechnology Vol. 107)

Green Gene Technology: Research in an Area of Social Conflict (Advances in Biochemical Engineering / Biotechnology Vol. 107)
Springer | ISBN:3540713212 | Edition - 2007-07-20 | PDF | 287 pages | 2.97 MB | Rapidshare & Megaupload

Advances in Biochemical Engineering/Biotechnology reviews actual trends in modern biotechnology. Its aim is to cover all aspect sof this interdisciplinary technology where knowledge, methods and expertise are required for chemistry, biochemistry, micro-biology, genetics, chemical engineering and computer science. Specia lvolumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. They give the state-of-the-art of a topic in a comprehensive way thus being a valuable source for the next 35 years. It also discusses new discoveries and applications. Special volumes are edited by well known guest editors who invite reputed authors for there view articles in their volumes.
Download

Rapidshare

Megaupload

Aliceinwire

Aging of the Genome: The Dual Role of DNA in Life and Death

Aging of the Genome: The Dual Role of DNA in Life and Death
Publisher: Oxford University Press | Language: English | ISBN: 019856922X | 327 pages | Data: 2007 | PDF | 3 Mb

Description: Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

Download:
MegaUpload
Easy-share

Regulation of Gene Expression: Molecular Mechanisms

Regulation of Gene Expression: Molecular Mechanisms
Humana Press | 1588292657 | Edition - 2006 | PDF | 333 pages | 2.88 MB | Rapidshare & Megaupload

Regulation of Gene Expression: Molecular Mechanisms presents a comprehensive overview of methods and approaches for characterizing mechanisms of gene regulation. The text is appropriate both as a graduate textbook and a standard laboratory reference and provides the essential groundwork for an advanced understanding of the various mechanisms that may result in altered activity of a specific cell protein.

Each of three sections explores mechanisms of gene regulation and expression, and presents methods and protocols for achieving specific experimental goals. Part I focuses on approaches for studying control of mRNA expression and determining target genes for a given transcription copy. Part II outlines the methods for determining how proteins can regulate each other by mediating synthesis, degradation, protein-protein interactions, and posttranslational modification. Part III explores how gene targeting techniques in mice can provide insight into protein function. This volume provides a clear, concise overview of the protocols and techniques used to examine chemically or disease-mediated alterations in gene expression in mammalian systems.
Download

Rapidshare

Megaupload

The Genetics of Male Fertility

Douglas T., Ed. Carrell, "The Genetics of Male Fertility"
Humana Press; 1 edition (2004) | ISBN: 1588298639 | 337 pages | PDF | 2,1 Mb

Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments.

This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms.

Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities.
Download
Depositfiles
Mirror

Gene Mapping, Discovery, And Expression: Methods And Protocols (Methods in Molecular Biology, Vol 338)

Gene Mapping, Discovery, And Expression: Methods And Protocols (Methods in Molecular Biology, Vol 338)
Humana Press | 1588295753 | Edition - 2006 | PDF | 334 pages | 3.71 MB | Rapidshare & Megaupload

A collection of cutting-edge computational tools and experimental techniques to study how genes are regulated, and to reconstruct the regulatory networks through which various cell-types are produced. On the computational side, web-based technologies to localize genes, to access and retrieve data from microarray databases, to conduct comparative genomics, and to discover the potential "codes" in genomic DNA that may control the expression of protein-coding genes. Detailed experimental techniques described include methods for studying chromatin structure and allele-specific gene expression, methods for high-throughput analysis to characterize the transcription factor binding elements, and methods for isolating and identifying proteins that interact with DNA. The protocols follow the successful Methods in Molecular Biologyâ„¢ series format, each offering step-by-step instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding pitfalls.
Download

Rapidshare

Megaupload

Aliceinwire

Genetics: A Conceptual Approach

Benjamin Pierce, "Genetics: A Conceptual Approach"
W. H. Freeman | ISBN: 1572591609 | December 20, 2002 | PDF | 736 pages | 15730 KB

Designed for introductory genetics courses, "Genetics: A Conceptual Approach" focuses on the important concepts and mechanics of genetics without losing students in a sea of detail. Drawing on more than 20 years of teaching experience, the author makes this often complex subject seem clear and accessible by making important connections between topics, providing advice and encouragement at difficult places, and describing the people, places, and experiments of genetics that make the subject interesting and alive.
Download
Rapidshare
xUploading.com
mirror

Principles of Developmental Genetics

Principles of Developmental Genetics
Academic Press | 0123695481 | Edition - 2007-06-29 | PDF | 1104 pages | 14.2MB

Unlike anything currently available in the market, Dr. Sally A. Moody and a team of world-renowned experts provide a groundbreaking view of developmental genetics that will influence scientific approaches in embryology, comparative biology, as well as the newly emerging fields of stem cell biology and regenerative medicine. Principles of Developmental Genetics highlights the intersection of developmental biology with new revolutionary genomic technologies, and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. This definitive resource provides researchers with the opportunity to gain important insights into the clinical applicability of emerging new technologies and animal model data. This book is a must-have for all researchers in genetics, developmental biology, regenerative medicine, and stem cell biology.
Download

Rapidshare

Megaupload

Building Genetic Medicine

Building Genetic Medicine
The MIT Press | 0262162423 | Edition - April 1, 2007 | PDF | 285 pages | 1.8 MB | 584 pages | rapidshare

In Building Genetic Medicine, Shobita Parthasarathy shows how, even in an era of globalization, national context is playing an important role in the development and use of genetic technologies. Focusing on the development and deployment of genetic testing for breast and ovarian cancer (known as BRCA testing) in the United States and Britain, Parthasarathy develops a comparative analysis framework in order to investigate how national "toolkits" shape both regulations and the architectures of technologies and uses this framework to assess the implications of new genetic technologies.

BRCA testing was one of the most highly anticipated and publicized technologies of contemporary medicine. Parthasarathy argues that differences in the American and British approaches to health care and commercialization of research led to the establishment of different BRCA services in the two countries. In Britain, the technology was available through the National Health Service as an integrated program of counseling and laboratory analysis, and was viewed as a potentially cost-effective form of preventive care. In the United States, although BRCA testing was initially offered by a number of providers, one company eventually became the sole provider of a test available to consumers on demand.

Parthasarathy also reports on an unsuccessful attempt by the American provider of BRCA testing to market its services in Britain. British scientists, health-care providers, and patients rejected the American technology, she argues, because it was part of a social, economic, and political system to which they were not accustomed. Parthasarathy draws lessons for the future of genetic medicine from these cross-national differences, and discusses the ways in which comparative case studies can inform policy-making efforts in science and technology.
Download

Rapidshare
Depositfiles

Megaupload

Regulatory RNAs

Regulatory RNAs
Cold Spring Harbor Laboratory Press | 0879698187 | Edition - 2007-06-30 | PDF | 550 pages | 20 MB | rapidshare

This Symposium was attended by 469 scientists from over 25 countries, and the program in-cluded 70 oral presentations and 209 poster presentations. Essential funds to run this meeting were obtained from the National Cancer Institute, a branch of the National Institutes of Health. In addition, financial help from the corporate benefactors, sponsors, affiliates, and contributors of our meetings program is essential for these Symposia to remain a success, and we are most grateful for their continued support.
Download

Rapidshare

Megaupload
Depositfiles

Yeast Gene Analysis 2nd edition (Methods in Microbiology: Vol 36)

Yeast Gene Analysis 2nd edition (Methods in Microbiology: Vol 36)
Academic Press | 0123694787 | Edition - July 9, 2007 | PDF | 700 pages | 11.7 MB | rapidshare

Focusing on Saccharomyces cerevisiae, the second edition of Yeast Gene Analysis represents a major reworking of the original edition, with many completely new chapters and major revisions to all previous chapters. Originally published shortly after completion of the yeast genome sequence, the new edition covers many of the major genome-wide strategies that have been developed since then such as microarray analysis of transcription, synthetic gene array studies, protein microarrays and chemical genetic approaches. It represents a valuable resource for any research laboratory using budding yeast as their experimental system in which to identify new yeast gene functions. The chapters are written in a readable style with useful background information, technical tips and specific experimental protocols included as appropriate, enabling both the novice and the experienced yeast researcher to adopt new procedures with confidence.

New chapters on:
* strain construction
* genome-wide two-hybrid approaches
* use of microarrays for transcript analysis
* real-time analysis of chromosome behaviour and FRET
* synthetic gene array technology and protein arrays
* chemical genomics and yeast prions
* RNA gene analysis and mitochondrial gene function analysis
* phylogenetic footprinting
* discovering human gene function and predicting yeast gene function
Download

Rapidshare
Depositfiles

Megaupload

Handbook of Immune Response Genes

Handbook of Immune Response Genes

Springer | ISBN:0306456478 | Edition - 1998-01-31 | PDF | 393 pages | 522 MB | rapidshare

In a vast and rapidly growing body of information, the researcher, clinician and student need resources which bring into focus the latest developments in our understanding of the vertebrate immune system. A concise and up-to-date reference, Handbook of Immune Response Genes does just that. Starting with a brief overview of specific components of the immune system, the authors lead readers toward an understanding which suggests further study. Extensive referencing and a detailed table summarizing the list of CD antigens reinforce this goal.

Download
Rapidshare

Analysis of Genes and Genomes

Richard J. Reece, «Analysis of Genes and Genomes»
John Wiley & Sons | ISBN 0470843799 | 2004 Year | PDF | 7,61 Mb | 490 Pages

This beautifully illustrated textbook provides a clear guide to the tools and techniques of genetic engineering, gene cloning and molecular biology. All aspects of genetic engineering in the post-genomic era are covered, beginning with the basics of DNA structure and DNA metabolism. Using an example-driven approach, the fundamentals of creating mutations in DNA, cloning in bacteria, yeast, plants and animals are all clearly presented.

Download from Rapidshare
Password (if required):: www.AvaxHome.ru