Current Topics in Innate Immunity (Advances in Experimental Medicine and Biology)

Current Topics in Innate Immunity (Advances in Experimental Medicine and Biology)
Springer | 038771765X | Edition - 2007-08-22 | PDF | 438 pages | 13.7 MB | Rapidshare & Megaupload

Innate Immunity has long been regarded as the non-specific arm of immune response, acting immediately and in a generic way, to defend the host from infections. In the post genomic era, our knowledge of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. Several studies indicate that molecules involved in innate immunity exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system.

The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led scientists to revisit established biological systems from a global and integrative perspective. Innate Immunity research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. In this respect, scientists from around the world convened at the 4th International Conference on Innate Immunity (June 4 - 9, 2006), in Corfu, Greece to discuss recent advances in this fast evolving field.

This volume represents a collection of topics on natural killer cells, mast cells, phagocytes, toll like receptors, complement, host defense in plants and invertebrates, evasion strategies of microorganisms, pathophysiology, protein structures, design of therapeutics, and experimental approaches discussed during the conference.
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Hepatitis Delta Virus (Current Topics in Microbiology and Immunology)

Hepatitis Delta Virus (Current Topics in Microbiology and Immunology)
Springer | ISBN: 3540298010 | Edition - 2006-06-14 | PDF | 228 pages | 2.64 Mb

Hepatitis delta virus which causes severe acute and chronic liver disease was discovered following the detection of a novel antigen-antibody system in hepatitis B virus carriers. Currently, HDV is classified as a subviral satellite of hepatitis B virus. However, unlike other satellite viruses, the dependence of HDV on HBV is limited solely to the provision of an envelope of hepatitis B surface antigen for virus assembly. Research into the molecular virology of the HDV life cycle has revealed a fascinating collection of biology. These insights are now beginning to be translated into new potential treatment strategies. There are currently still an estimated 15 million HDV carriers worldwide.
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Handbook of Immune Response Genes

Handbook of Immune Response Genes

Springer | ISBN:0306456478 | Edition - 1998-01-31 | PDF | 393 pages | 522 MB | rapidshare

In a vast and rapidly growing body of information, the researcher, clinician and student need resources which bring into focus the latest developments in our understanding of the vertebrate immune system. A concise and up-to-date reference, Handbook of Immune Response Genes does just that. Starting with a brief overview of specific components of the immune system, the authors lead readers toward an understanding which suggests further study. Extensive referencing and a detailed table summarizing the list of CD antigens reinforce this goal.

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Cytokines and Chemokines in Infectious Diseases Handbook (Infectious Disease)

Cytokines and Chemokines in Infectious Diseases Handbook (Infectious Disease)
Humana Press| 896039080 | Edition - 2003-03-03 | PDF | 456 pages| 3.77 MB | Rapidshare &Megaupload

A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.
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General Principles of Tumor Immunotherapy: Basic and Clinical Applications of Tumor Immunology

General Principles of Tumor Immunotherapy: Basic and Clinical Applications of Tumor Immunology
Publisher: Springer | Language: English | ISBN:1402060866 | 504 pages | Data: 2007 | PDF | 3 Mb

Description: "General Principles of Tumor Immunotherapy: Basic and Clinical Applications of Tumor Immunology" brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated through both experimental clinical trials and review of current standard of care therapeutic agents. This information will be invaluable to both students of immunology and cancer research and practicing physicians who have patients with cancer. The book provides a comprehensive overview of the field, demonstrates how advances in basic immunology can and are being applied to cancer, and describes the current status of approved immunotherapy regimens.

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Mechanisms of Lymphocyte Activation and Immune Regulation XI: B Cell Biology

Mechanisms of Lymphocyte Activation and Immune Regulation XI: B Cell Biology

Publisher: Springer | Language: English | ISBN:0387465278 | 208 pages | Data: 2007 | PDF | 2.3 Mb

Description: In recent years, major developments have been made in understanding various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. A role and mechanism of DNA repair proteins in somatic hypermutation has been elucidated. Genetic mutation studies have been instrumental in providing insight into some of the mechanisms involved in targeting CSR to various switch DNA regions located upstream of C region genes, especially a role of AID motifs, transcription, and R-loops. Recent studies support a dominant role of receptor editing in central B cell tolerance and signaling pathways that regulate receptor editing in self-reactive and non-self-reactive immature B cells. These were some of the topics of discussion at the 11th International Conference on B cell Biology. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.

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